60 Degrees Pharmaceuticals Announces Partnership with The University of Southern Mississippi to Evaluate Castanospermine in Nonclinical Models of Alpha-Gal Syndrome

Company plans to explore botanical approval pathways before initiating a prescription drug development program

WASHINGTON, Oct. 28, 2026 (GLOBE NEWSWIRE) -- 60 Degrees Pharmaceuticals, Inc. (NASDAQ: SXTP; SXTPW) (the “Company”), a pharmaceutical company focused on developing new medicines for vector-borne diseases, today announced expansion of its vector-borne disease research portfolio through a sponsored research agreement with The University of Southern Mississippi (USM) to assess the therapeutic potential of castanospermine—a naturally occurring iminosugar derived from the Australian Chestnut (Castanospermum australe)—in nonclinical models of alpha-gal syndrome (AGS).

The partnership leverages USM’s established vector biology research expertise and investigator insights into tick-borne disease. Under this agreement, 60 Degrees will underwrite the research and retains an option to commercialize and market any resulting intellectual property.

As part of its development strategy, the Company plans to explore potential botanical approval pathways for a castanospermine-containing product before embarking on a prescription drug (Rx) development program. The nonclinical research at USM is expected to help inform this assessment and guide subsequent development decisions.

AGS is an increasingly recognized tick-associated allergic condition, most commonly linked in the United States to bites from the lone star tick. AGS can cause severe and potentially life-threatening allergic reactions following ingestion of, or exposure to, products containing galactose-α-1,3-galactose (alpha-gal), a carbohydrate found in most non-primate mammalian meat and other mammalian-derived products, including beef, pork, lamb, and certain dairy products. Humans do not produce alpha-gal and may develop antibodies against it following tick exposure. There are currently no FDA-approved medications specifically indicated to treat or prevent AGS, and current condition management relies primarily on avoidance of foods and other products that trigger allergic reactions.

About 60 Degrees Pharmaceuticals, Inc.
60 Degrees Pharmaceuticals, Inc., founded in 2010, develops and commercializes new medicines for the treatment and prevention of vector-borne disease. The Company obtained U.S. Food and Drug Administration approval of its lead product, ARAKODA^® (tafenoquine), for malaria prevention in 2018 and currently has 3 active clinical trials underway for babesiosis, an emerging tick-borne disease. 60 Degrees also collaborates with prominent research and academic organizations in the U.S. and Australia to advance science around vector-borne disease. The Company is headquartered in Washington, D.C., with a subsidiary in Australia. Learn more at www.60degreespharma.com.

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Media Contact:
Kristen Landon
kristenlandon@60degreespharma.com

Investor Contact:
Patrick Gaynes
patrickgaynes@60degreespharma.com